Gravettian cranial morphology and human group affinities during the European Upper Palaeolithic. Radiocarbon 55, 163177 (2013). PubMed Central About the author: Tina Huang is a data scientist at one of the FAANG companies. Data Engineer Cover Letter Sample and Template. Sikora, M. et al. Nature 615, 117126 (2023). In the MDS plot, the Le Piage II individual falls particularly close to individuals belonging to the Fournol cluster, suggesting a local genetic continuity of this ancestry during the LGM (Supplementary Fig. Lifetime access to all course materials and updates. Kircher, M., Sawyer, S. & Meyer, M. Double indexing overcomes inaccuracies in multiplex sequencing on the Illumina platform. Sci. Her YouTube channel advises data science jobs, self-study, boosting productivity, resume reviews, etc. Science 344, 747750 (2014). Tina Huang. The inferred pattern of short ROH (48 cM, visualized in blue) being common is in stark contrast to most later farmer populations, where the majority of individuals have no short ROH whatsoever (see101), and evidences small effective population sizes across West Eurasian hunter-gatherer groups. Jones, E. R. et al. Ruiz-Redondo, A. et al. Fog computing is a computing structure which is distributed in nature. Extended Data Fig. Science 328, 710722 (2010). I hold a Bachelor's degree at the University of Toronto where I studied pharmacology. Cambridge Archaeol. Ongoing symptoms 3 months after infection by SARS-CoV-2 are well described as long COVID and have become a global health concern [1], [2].Fatigue and dyspnea are the two most common symptoms after infection by SARS-CoV-2 and low physical performance impacting daily activities has been described for up to 6 months after infection [3]. Great content - Tina is all class and an excellent instructor. However, the level of genetic continuity between individuals associated with these cultures and the population structure among Epigravettian-associated individuals have not been fully explored. 3.Tina Huang. The newly defined Fournol cluster is closely related to Aurignacian-associated individuals from Belgium dated to 35ka (Goyet Q116-1 and the newly reported Goyet Q376-3 individual). You are using a browser version with limited support for CSS. Check out Why is Burnout So Common in Tech? Olalde, I. Human bones and teeth were sampled in clean room facilities to minimize the inclusion of modern human DNA contamination during this procedure. PubMed 4a and Supplementary Data 3.C). Consistent with previous findings, none of the analysed groups show the derived allele at SNP rs4988235 on the LCT gene, which is responsible for lactase persistence. 29, 11691177.e7 (2019). Nat. People with a new gene pool settled in these areas, instead. Anti Slip Coating UAE Then we merged the genotypes from different libraries of the same individual, by randomly picking alleles from available genotype calls, using a custom script. This Villabruna ancestry(hereafter, Villabruna cluster or ancestry) showed connections to ancient and present-day Near Eastern populations4,16, but the mode and tempo of its expansion into the Italian peninsula remain unexplored. Tina Huang hellotinah@gmail.com | 123-456-7890 | 1 BeepbeepBoop St. Philadelphia, PA 19104 EDUCATION AND HONORS University of Most data scientists are used to having to do the dirty work of cleaning and cleansing data. Complete mitochondrial genome sequence of a Middle Pleistocene cave bear reconstructed from ultrashort DNA fragments. An expert in the industry, and a tireless advocate for improving it, Areej AbuAli is an inspiring person for those in the SEO space. We also do experiments to test out the features we build and see how users respond to them. The Complete Power BI Practical Course 2020, The 7 Biggest Technology Trends Everyone Must Get Ready For in 2020. E.A. Commun. Peltzer, A. et al. 14), most post-14ka individuals from western and central Europe fall close to the WHG cluster and those from eastern Europe close to the EHG cluster, whereas the Tutkaul 1 individual from central Asia falls close to the ANE-related group. Our results show that the contact zone and the admixture patterns betweenthe Oberkassel and Sidelkino ancestries changed over time (Fig. of estimates from 5-cM-block jackknife analysis. Curr. Evol. Nat. In the first place, we have traditional analysis. Bronk Ramsey, C. Bayesian analysis of radiocarbon dates. Ice Age survivors. As a general rule of thumb, we start from the simplest issue and gradually increase in complexity. We report 47 new radiocarbon dates performed on skeletal elements of 40 individuals by the Curt-Engelhorn-Zentrum Archaeometrie in Mannheim (MAMS, n=29), Center for Isotope Research, University of Groningen (GrA and GrM, n=5), University of Aarhus (AAR, n=3), Beta Analytics (Beta, n=2), Zrich (ETH, n=3), International Chemical Analysis (ICA, n=2), Natural History Museum in Paris (Echo Lab, n=1) and Vilnius (FTMC, n=2) (Supplementary Data 1.A). 1 MtDNA and Y-chromosome phylogenies. 27 and 28). The mtDNA contamination was estimated by Schmutzi (--notusepredC --uselength)69 for all the libraries. One of my favorite videos of her is where she talks about the resume that got her an entry-level data science job. Junior Data Scientist May 2017 - April 2018. Instead, for the two SNPs associated with skin colour (SLC24A5 (rs1426654) and SLC45A2 (rs16891982)), Sidelkino clusterand Ukraine HG groups show a higher frequency (>90% for SLC24A5 and 2961% for SLC45A2) of the derived alleles related to light skin colour, compared with Oberkassel and Villabruna clusters, where those alleles are almost completely absent (<1%). 1c). During this time agriculture and a sedentary lifestyle spread from Anatolia to Europe. Third, Magdalenian-associated individuals not only from Iberia but also from the rest of Europe carry Epigravettian-associated ancestry (Villabruna cluster). Nature 534, 200205 (2016). Yu, H. et al. Next, we investigated the genetic relationships between Epigravettian-associated individuals across the Italian peninsula, by reconstructing a phylogeny based on a matrix of pairwise f2 genetic distances (Fig. In the video above, she explains the two major components of big data: data warehousing and data science. We love meeting interesting people and making new friends. Genome Biol. However, the extent to which groups associated with the Solutrean culture are in genetic continuity with earlier and later populations from the same region is unknown because no genomic data from Solutrean-associated individuals have been reported previously. Enjoy maximum flexibility and forget about cramming against the clock. Hi! 771234-PALEoRIDER (to W.H. Skoglund, P. et al. There is no biographical data to display. The White House and federal agencies in the U.S. declare the Year of Open Science, listing several actions towards open science. The lsqproject: YES parameter was used to minimize the effect of missing data in ancient individuals. 4 Admixture graph modelling of pre-34 ka hunter-gatherer lineages. Cosimo Posth, He Yu or Johannes Krause. We visualize the total amount of ROH longer than 4 cM for (a) pre-LGM individuals, (b) Epigravettian- and Magdalenian-associated individuals, (c) individuals carrying high proportions of Sidelkino-related ancestry, and (d) individuals carrying high proportions of Oberkassel-related ancestry. Disease-modifying, readily available, and easily affordable medical therapies for hypertension are ubiquitous and set a high bar for any new therapeutic. As the coverage for most ancient samples was not sufficient for diploid genotype calling, we counted the reads covering selected phenotypic SNPs on reference or alternative alleles and computed the group-based allele frequencies following a maximum likelihood approach described in Mathieson et al.37. ather than doing some data analysis or looking at trends, we wanted to dedicate this bulletin to seven women in tech, data, and science that you should know about. 10, 552010 (2019). In her journey of eventually becoming a data scientist, Tina started out with an undergraduate in Pharmacology. An early modern human from Romania with a recent Neanderthal ancestor. The detailed grouping of individuals shown with empty coloured circles is described in Supplementary Data 1.I. Note: Content may be edited for style and length. Tina K. Sorensen. Jagwire Europe - Fevacom NV . Villalba-Mouco, V. et al. Article We then attempted to model 250 published and newly reported hunter-gatherers dated to 145ka using qpAdm as a mixture of Oberkassel, Sidelkino, GoyetQ2 ancestries, and an ancestry maximized in Anatolian Neolithic farmers (ANF), as a considerable portion of the sequenced hunter-gatherer genomes date after around 8ka, when ANF ancestry started spreading across Europe. I'm I've learned SQL before, but I need a refresher. 71, 465492 (2015). Tina Huang Popularity . A dynastic elite in monumental Neolithic society. Article The oldest individual revealing an indistinguishable genetic profile from the Yuzhniy Oleniy Ostrov group is the 11ka Sidelkino individual from Samara in western Russia42. CNRS, MNHN, Universit de Paris Cit, Muse de lHomme, Paris, France, PALEVOPRIM Lab UMR 7262 CNRS-INEE, University of Poitiers, Poitiers, France, Centre de Valorisation des Collections Scientifiques, Universit de Poitiers, Mignaloux Beauvoir, France, Muses de PoitiersVille de Poitiers, Poitiers, France, Departamento de Geologa, Facultad de Ciencia y Tecnologa, Universidad del Pas Vasco/Euskal Herriko Unibertsitatea (UPV/EHU), Leioa, Spain, Sociedad de Ciencias Aranzadi, Donostia-San Sebastian, Spain, Centro UCM-ISCIII de Investigacin sobre Evolucin y Comportamiento Humanos, Madrid, Spain, Institute of Archaeology, University of Rzeszw, Rzeszw, Poland, Foundation for Rzeszw Archaeological Centre, Rzeszw, Poland, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA, Department of Psychiatry, Harvard Medical School, Boston, MA, USA, Groninger Instituut voor Archeologie, Groningen University, Groningen, The Netherlands, Institute of Archaeology and Ethnology, Polish Academy of Science, Pozna, Poland, Institute of History, Archaeology and Ethnography, Dushanbe, Tajikistan, ArchaeoZOOlogy in Siberia and Central AsiaZooSCAn, CNRSIAET SB RAS International Research Laboratory, IRL 2013, Institute of Archaeology SB RAS, Novosibirsk, Russia, Research Institute and Museum of Anthropology, Moscow State University, Moscow, Russia, Grupo de I+D+i EVOADAPTA (Evolucin Humana y Adaptaciones durante la Prehistoria) Departamento de Ciencias Histricas, Universidad de Cantabria, Santander, Spain, Borja Gonzlez-Rabanal,Ana B. Marn-Arroyo&Lawrence G. Straus, Instituto Internacional de Investigaciones Prehistricas de Cantabria (IIIPC), Universidad de Cantabria-Gobierno de Cantabria-Banco Santander, Santander, Spain, Departamento de Biologa de Organismos y Sistemas, Universidad de Oviedo, Oviedo, Spain, Quaternary Environments and Humans, OD Earth and History of Life, Royal Belgian Institute of Natural Sciences, Brussels, Belgium, Caroline Polet,Ivan Jadin&Sbastien Villotte, Muses Royaux dArt et dHistoire, Bruxelles, Belgium, Institute of Historical Research, University of Girona, Catalonia, Spain, Joaquim Soler,Neus Coromina&Isaac Ruf, INRAP/UMR 8215 Trajectoires 21, Paris, France, School of Human Evolution and Social Change, Arizona State University, Tempe, AZ, USA, Department of Anthropology, University of New Mexico, Albuquerque, NM, USA, GoArchPal-GoArchon, Viville sous-les-Cotes, France, Archologie & Mnzkabinett, Universalmuseum Joanneum, Graz, Austria, Museum Das Dorf des Welan, Wllersdorf-Steinabrckl, Austria, Department of Humanities, University of Ferrara, Ferrara, Italy, National Museum of Antiquities, Leiden, The Netherlands, Faculty of Archaeology, Leiden University, Leiden, The Netherlands, Biogeology, Department of Geosciences, University of Tbingen, Tbingen, Germany, Unit de Recherches Art, Archologie Patrimoine, Universit de Lige, Lige, Belgium, I.U. Tina Huang Is A Member Of . 6 and Supplementary Fig. Renaud, G., Slon, V., Duggan, A. T. & Kelso, J. Schmutzi: estimation of contamination and endogenous mitochondrial consensus calling for ancient DNA. Article Evol. I'm a data scientist and youtuber. Otte, M.) 105160 (Errance, 2013). Nat. Ideally, we also want lots of data because this will give us more confidence in our results. Our capabilities include CNC machining, sheet metal For consistency with the previously discussed nomenclature, we rename the EHG ancestryas the Sidelkino cluster(hereafter, Sidelkino cluster or ancestry). A 5700 year-old human genome and oral microbiome from chewed birch pitch. 16, e2003703 (2018). This finding, in conjunction with the genetic affinity of the Villabruna cluster to ancient and present-day Near Eastern ancestries4,15,16 (Supplementary Information, section8, Supplementary Fig. Rep. 10, 21931 (2020). Epoxy Flooring UAE; Floor Coating UAE; Self Leveling Floor Coating; Wood Finishes and Coating; Functional Coatings. Overall, the Solutrean-associated Le Piage II individual links the preceding Fournol ancestry with the succeeding ancestry found in El Mirn, providing direct evidence for genetic continuity throughout the LGM in southwestern and western Europe. Newsletter, We then removed samples with less than 0.04X coverage (calculated on the mappable, non-recombining region of the Y chromosome98) to avoid arbitrarily placing low-coverage samples at the root of major haplogroups. Tina Huang is a statistician who focuses on the statistical modeling and analysis of big data. The first horse herders and the impact of early Bronze Age steppe expansions into Asia. The previously described Vstonice cluster, including a newly reported 29,000-year-old individual from Paglicci cave (Paglicci 12) in southern Italy, is closely related to the previously published genomes from Sunghir and Kostenki 12 in western Russia, which are dated to 34ka and 32ka, respectively4,23. After 2 washing steps using the manufacturers wash buffer, DNA was eluted in TET (10mM Tris, 1mM EDTA and 0.05% Tween) in two steps for a final volume of 100l. 4. In central-western Europe, Gravettian-associated individuals from Goyet show affinity to both clusters. Dots are maximum likelihood estimates and error bars show 95% confidence intervals of the derived allele frequencies (n, the number of individuals in each group, is provided in Supplementary Data 3.G). An equimolar pool of all libraries was then prepared for shotgun sequencing on Illumina Hiseq4000 platform using 75bp single-end reads for screening. 14, evac045 (2022). Libraries showing a mitochondrial or nuclear contamination rate over 10% were considered substantially contaminated whereas those between 5 and 10% were considered marginally contaminated and were treated differently (details are provided in Supplementary Information, section3). Open access funding provided by Max Planck Society. 6, 16581668 (2022). The resulting GoyetQ2 cluster includes individuals spanning from western France to Poland in the period between 18 and 15ka. 1) we used MUSCLE (-maxiters 2)96 to create a multiple genome alignment of previously published sequences and newly reported mtDNA consensus sequences with q20 according to defined thresholds (minimum average coverage >5-fold, contamination estimate <20%, HaploGrep2 haplogroup assignment consistent with manual assignment). The phylogenetic reconstruction of Epigravettian-associated genomes, with Pradis 1 diverging more deeply than all others, indicates that the turnover took place much earlier than 17kathe date of the more derived Tagliente 2 genome. Adv. Claim Author Page. Conversely, the ancestry found in pre-30ka eastern European individuals (Kostenki cluster and Sunghir group) contributed to Gravettian-associated individuals from central and southern Europe (Vstonice cluster), the latter without descendantsretrieved in post-LGM populations from those regions. 4). Commun. The team analysed the genomes of 356 prehistoric hunter gatherers from different archaeological cultures -- including new data sets of 116 individuals from 14 different European and Central Asian countries. Pleistocene North African genomes link Near Eastern and sub-Saharan African human populations. Article Nature thanks Marta Mirazn Lahr, Ludovic Orlando and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Sign up for the Nature Briefing newsletter what matters in science, free to your inbox daily. Article Ecologizr. Planning and Learning in Partially Observable Systems via Filter Stability Noah Golowich (MIT); Ankur Moitra (Math & CSAIL, MIT); Dhruv Rohatgi (MIT) New Subset Selection Algorithms for Low Rank Approximation: Offline and Online David P. Woodruff, Taisuke Yasuda (Carnegie Mellon University) Good Quantum LDPC Codes with Linear Time Decoders Irit Dinur (Weizmann); Min-Hsiu Hsieh (Hon Hai Quantum . 1). Rohland, N. & Hofreiter, M. Ancient DNA extraction from bones and teeth. Moreover, none of the Epigravettian-associated individuals have more affinity to southern European than to central-eastern European Gravettian-associated groups, as shown by f4(Mbuti, Epigravettian-associated individual/group; Vstonice, Paglicci 12) that is consistent with 0 (Supplementary Data 2.G). Revise SQL essentials, improve your communication style and tackle the most challenging follow-up questions with ease. My name is Tina and I'm a data scientist and YouTuber. Once we have the data, we begin to tease out the high-impact insights. Seguin-Orlando, A. et al. However, the research team found no evidence for this, on the contrary: hunter-gatherer populations associated with the Gravettian culture and living in central and southern Europe are no longer genetically detectable after the LGM. These f4-statistics also confirm that Goyet Q376-3 carries a similar ancestry to Goyet Q116-1 and Kostenki 12 carries a similar ancestry to the Sunghir group, whereas Bacho Kiro 1653 (35ka) from Bulgaria, Muierii 1 (34ka) and Cioclovina 1 (32ka) from Romania, and Paglicci 133 (33ka) from southern Italy are equally related to Goyet Q116-1 and Sunghir. I worked in bioinformatics in cancer research and then decided to a masters in computer science (MCIT) from the University of . F-statistics suggest that Le Piage II is genetically intermediate between Fournol 85 and El Mirn (Supplementary Data 2.D). Data warehousing is a field that has to be done right. Straus, L. G. The human occupation of southwestern Europe during the Last Glacial Maximum: Solutrean cultural adaptations in France and Iberia. While terms such as lithic industry, techno-complex, prehistoric tradition, and so on might be more appropriate to refer to the various associated chrono-cultural subdivisions, they concern different levels of discussion and are not applicable to all contexts investigated here. She then pursued a Masters . Este botn muestra el tipo de bsqueda seleccionado. The Neolithic transition in the Baltic was not driven by admixture with early European farmers. What is Marimekko Chart in Data Visualization? PubMed Tina Huangis a data scientist currently working at a large FAANG enterprise. I am Tina Huang, PhD, a data scientist, and the director of the Data Science Learning Center at the University of Arizona. Article Huang's parents immigrated to New York City where her two older brothers . Big data data warehousing and data science are two sub-tasks of a larger endeavor called data science, which is a sub-tasks of data science. & Zimmermann, A. A. Stoessel performed CT scanning and advised on sampling strategy. These models are easy to implement as well as really helpful in deciding what to build and how much to invest in it. In sum, we describe the formation and interaction between the Oberkassel and Sidelkino clusters, the two main hunter-gatherer ancestries present in Europe from 14ka onwards. The sample size of individualpairsincluded in each groupis reported in SupplementaryData 3.A. . At this startup dedicated to b2b marketing, we, the data team formed by 2 people, are organizing all the data from zero and looking for their real value.